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Cerebral Infarction Associated with Protein C Deficiency Stroke 23:108-111, Matsushita,K.,et al, 1992 See this aricle in Pubmed Article Abstract We treated a young woman with protein C deficiency,who had developed a cerebral infarction of the right parietal cortex of sudden onset.On admission,the antigenic level of plasma protein C was 38%.Serial cerebral angiography revealed occlusion of the right middle cerebral artery,which subsequently recanalized completely.This patient had taken fluorouracil derivatives orally for as long as 3 years following a left mastectomy for stage II breast cancer.Tests revealed that the patient's mother had only one-half the normal activity of plasma protein C despite a normal antigenic level.We speculate that the etiology of the cerebral infarction in this patient might involve an embolic mechanism associated with protein C deficiency induced by an interaction between inherited and acquired factors.

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